An Elixhauser comorbidity index of 3 (adjusted odd ratio [aOR], 2.36; 95% confidence interval [CI], 1.194.69) and sepsis (aOR, 2.44; 95% CI, 1.404.24) were independently associated with 30-day all-cause mortality (Table 1). You can read the show notes for this episode and subscribe to our mailing list on our website. Careers. Audio edited by Clair Morgan ofNodderly.com. cSome patients had more than 1 infectious source. WebUnderstand that cefepime can induce neurotoxicity by blocking the GABA receptor, similar to how other beta-lactam antibiotics can induce neurotoxicity, particularly seizures but This evaluation Published by Oxford University Press on behalf of Infectious Diseases Society of America. The Quote of The Day Show is your daily dose of inspiration, featuring the best-of-the-best speakers and prosperity teachers. Unauthorized use of these marks is strictly prohibited. This episode is sponsored by BetterHelp! Positive impact of [18F]FDG-PET/CT on mortality in patients with Staphylococcus aureus bacteremia explained by immortal time bias. Cefepime-induced neurotoxicity (CIN) has been well acknowledged among clinicians, although there are no clear diagnostic criteria or specific laboratory testing to help with its diagnosis. You can follow Hannah on Twitter at @hannahrabrams. Hamada Cefepime is a fourth-generation cephalosporin usually reserved to treat severe infections or those caused by multi-resistant microorganisms. We applied the new breakpoint on 644 previously defined cefepime-susceptible Enterobacteriaceae isolates. In the current situation where there are no CIN diagnostic criteria and the drug monitoring platform is not routinely available, candidates for cefepime should be carefully selected. The study will be conducted in approximately 115 sites located in the EU, the US, Central, South America and South Africa. Remember to pick CME/MOC credit just for listening to the episode! Episode 61 Of ticks, alpha-gal, and red meatallergies, Episode 49 Curious Incidents in theNighttime, Episode 46 The Man Who Purposefully ParalyzedHimself, Episode 45 (Trans)locating thebacteria, Episode 38 Thanksgiving & The FoodComa, Episode 36 The Mystery of MelanosisColi, Episode 35 The curious laterality of catamenialpneumothorax. On this episode of the podcast, The Curious Clinicians examine why drinking alcohol can lead to significant polyuria, what some refer to as "breaking the seal". Although our database was built to maximize comprehensiveness, ICD-9 CM codes may not accurately reflect the true infectious diagnosis and may result in misclassification bias. In this episode, The Curious Clinicians break down the evidence around this age-old medical teaching pearl. JF VCU Health Staff only - click Sign in with your VCU Health Login. On this episode, The Curious Clinicians explore why and how tumors in bones cause pain, with surprising results. Many of us struggle to get regular exercise, but even that can fall short of nourishing the body from head to toe. Check out the show notes here. However, this would also be particularly relevant in real-world practice, as accessibility to molecular assay may be limited. Audio edited by Clair Morgan of Nodderly.com. The site is secure. The Curious Clinicians took a quick holiday break and will be back with new episodes next week! WebMultiple regression was performed to assess the association between CRN, cefepime PK, and clinical predictors of neurotoxicity. The Curious Clinicians post our 50th episode this week! What are the mechanisms of treatments we use? As we approach our 50th episode, The Curious Clinicians reboot episode 24, asking why fever can actually be beneficial during infection? Potential conflicts of interest. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Attendance (0.5 hours), or ABIM MOC Part 2 (0.5 h, Why can heparin cause hyperkalemia? Episode 16: Why do Kayser-Fleischer rings form in the cornea in Wilsondisease? Seeking a healthier emotional life? Categorical variables were assessed using the 2 test, Fisher exact test, or univariable logistic regression, where appropriate. Abstracts of Presentations at the Association of Clinical Scientists 143. Episode 31: Why does nephrotic syndrome causeedema? . We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. The Curious Clinicians, Blog at WordPress.com. The Curious Clinicians examine why advanced systolic heart failure can induce the Cheyne-Stokes respiratory pattern. All authors: no reported conflicts of interest. Cefepime is a fourth-generation cephalosporin with a broad-spectrum antibacterial activity; it has been widely used since its approval for clinical use in 1997 [ 7 ]. Each episode spotlights an inspiring quote and 5-10 minute motivational audio clip to help you live a life you love. Thank you for joining us on this medical curiosity journey and thank you to the team that has helped take the podcast to the next level, including audio editor extraordinaire Clair Morgan from Nodderly and the VCU Health Continuing Education team! This is the second episode in a two-part series called "The Eyes Have It", where The Curious Clinicians explore questions related to the eye. Learn about why cryptococcal meningitis can cause such severe elevations in intracranial pressure, while often causing only minimal inflammation. In our cohort, 4.7% of the cefepime-SDD and cefepime-susceptible Enterobacteriaceae isolates phenotypically exhibited ESBL production. The best Podcast API to search all podcasts and episodes. You can support the podcast and pick up some sweet swag from our online store. Tony joined Dr. Adam Rodman as a guest on the Bedside Rounds podcast. In this episode, The Curious Clinicians take things to heart and unpack both why rheumatic heart disease so often involves heart valves, and why the mitral valve is by far the most commonly affected. Episode 5: How do diuretics lead to metabolicalkalosis? We cover why cefepime (and other beta-lactam antibiotics) can cause neurotoxicity. The Curious Clinicians dive into the history and physiologic effects of IV fluids and why saline is definitely not "normal". Avi, Hannah, and Tony investigate why the antibiotic azithromycin has anti-inflammatory properties. Each conversation is a three-part journey that distills the guests' greatest wisdom and methodologies into practical, transformative steps that anyone can use to create their own path to a life of freedom, grow A weekly weight loss podcast. NY In their latest episode, The Curious Clinicians investigate why antiphospholipid antibodies can be falsely positive during acute illness or thrombosis. and transmitted securely. Payne LE, Gagnon DJ, Riker RR, Seder DB, Glisic EK, Morris JG, Fraser GL. Show notes: https://curiousclinicians.com/?p=824. When the new breakpoint was applied, 26 (3.9%) isolates were re-categorized into cefepime-SDD, and 638 (96.1%) isolates remained cefepime-susceptible. Check out the show here! Patients were excluded if they met any of the following exclusion criteria: (1) Enterobacteriaceae with a cefepime disk diffusion diameter 18 mm; (2) polymicrobial bacteremia (ie, bloodstream infection with >1 organism); (3) cefepime discontinued <72 hours after the initial dose; (4) combination antimicrobial therapy; (5) death <48 hours Because this is a retrospective study, the 2014 CLSI recommendation of using high-dose cefepime would not have been applied to these previously collected Enterobacteriaceae isolates for 20052013. aComparison of 30-day all-cause mortality and microbiological failure. DM Search past episodes of The Curious Clinicians. , Ribeiro VB, Tessari JP, et al. They track the evolution and controversies of the death exam, from a trans-Atlantic scandal surrounding a possible vivisection, a 19th century X-prize to determine a technology that could diagnose death, the important distinction between permanent and irreversible, and the mysterious Lazarus phenomenon. The 2014 CLSI cefepime-SDD interpretative category was created based on a cefepime dosing regimen of 2 g Q8 hours [1]. Enter your Email address and click submit to have a login reset link sent to you. Hannah Abrams, MD is an internal medicine resident in Boston, MA. Additionally, we were unable to identify source control that may have contributed to variations in clinical outcomes. Hannah, Avi, and Tony break down why cancer leads to a hypercoagulable state, recalling the story of Armand Trousseau and exploring the roles of tissue factor and evading the immune system. Cefepime-induced Neurotoxicity: A Retrospective Cohort Study in a South-Indian Tertiary Healthcare Facility. On this episode, The Curious Clinicians examine why elevated triglycerides in the blood can cause pancreatitis. Neurocrit Care. Thank you for submitting a comment on this article. Thank you for helping to keep the podcast database up to date. The Curious Clinicians post our 50th episode this week! Emerging clinical data have reported higher mortality and inferiority of cefepime to carbapenems in treating ESBL-producing Enterobacteriaceae infection [3, 5, 14]. The Curious Clinicians is a medical podcast that asks "why?". 00:16:12 - The Curious Clinicians examine why we use a bacterial vaccine (BCG, an attenuated form of mycobacterium bovis) to treat an unrelated malignancy (bla Thank you for joining us on this medical curiosity journey and thank you to the team that has helped take the podcast to the next level, including audio editor extraordinaire Clair Morgan from Nodderly and the VCU The incidence of CRN was 4.4% (22/503). To overcome the limitations of previous studies, we used more rigorous inclusion criteria. Is oral furosemide absorption affected by gut edema in acute heart failure? Don't forget to pick up yourCME/MOC credits, courtesy of VCU Health! The Curious Clinicians outline a new theory about what, if any, genetic syndrome Abraham Lincoln may have had. The answer is more complicated than youd think. When shes not repleting potassium or rounding, Hannah is probably making terrible puns or talking about why platelets are the coolest part of the CBC. It works by stopping the The Curious Clinicians examine why propofol can cause propofol-related infusion syndrome (PRIS). Hannah, Avi and Tony examine why we feel cold while febrile (shouldn't we feel hot?) Why do diseases present in certain ways? 2023 VCU Health Continuing EducationContact us at (804) 828-3640 or[emailprotected]. Check out the show notes for this episode andread Avi's tweetorial on this topic. Was he treated with digitalis? The answer might surprise you! Results: You can also read Avi's original tweetorial on torsades and magnesium here. WebThe Curious Clinicians post our 50th episode this week! Rivera How can we medically tell whether or not someone is alive or dead? Read the show notes here. Variables were not normally distributed; thus, nonparametric tests were used. Check out Tony's companion tweetorial here. The Curious Clinicians examine why we use a bacterial vaccine (BCG, an attenuated form of mycobacterium bovis) to treat an unrelated malignancy (bladder cancer). Search for other works by this author on: Division of Infectious Diseases, Washington University School of Medicine, Veterans Affairs St. Louis Health Care System, Division of Laboratory and Genomic Medicine, Department of Pathology and Immunology, Washington University School of Medicine, Performance Standards for Antimicrobial Susceptibility Testing, Clinical and Laboratory Standards Institute, Effect of cefepime dose on mortality of patients with Gram-negative bacterial bloodstream infections: a prospective cohort study, Evaluation of clinical outcomes in patients with Gram-negative bloodstream infections according to cefepime MIC, Cefepime therapy for cefepime-susceptible extended-spectrum -lactamase-producing, Clinical outcomes in patients with gram-negative infections treated with optimized dosing cefepime over various minimum inhibitory concentrations, Impact of different measures of comorbid disease on predicted mortality of intensive care unit patients, Impact of revised cefepime CLSI breakpoints on, Impact of cefepime susceptible-dose-dependent MIC for. They inspect together why certain rashes have an acral distribution. For this, we categorized cefepime regimens into standard dosing of <6 g/d (eg, 1 g Q8 hours or 2 g Q12 hours) and high dosing of 6 g/d (ie, 2 g Q8 hours). Does that crossing serve a purpose? On this episode, The Curious Clinicians are joined by their first guest host, dermatologist extraordinaire Dr. Steven Chen! CIN patients commonly manifested altered mental status (93%), myoclonus (37%) and non-convulsive seizure epilepticus (28%). The Curious Clinicians is a medical podcast that asks "why?". The primary exposure of interest was cefepime susceptibility re-categorization of previously identified cefepime-susceptible Enterobacteriaceae isolates using the revised CLSI breakpoint, dichotomized into cefepime-susceptible and cefepime-SDD. Episode 27: Why can albuterol cause a lactic acidosis when given in highdoses? On this episode of the The Curious Clinicians, Tony, Avi, and Hannah explore why trimethoprim/sulfamethoxazole can cause an isolated rise in creatinine. The median latency period of developing CIN from cefepime initiation was 4 days, and about 12% developed CIN during empirical treatment. Correspondence: Kap Sum Foong, MD, University of Illinois College of Medicine at Peoria, Department of Medicine, 530 NE Glen Oak Ave., Peoria, IL 61637 (. Before MD Thus, we were unable to fully evaluate whether high-dose cefepime would have led to a more favorable outcome for patients with cefepime-SDD Enterobacteriaceae bacteremia. The Curious Clinicians unpack why potassium is often repleted to levels >4 mEq/L. Enjoy! Clinical, Electroencephalographic Features and Prognostic Factors of Cefepime-Induced Neurotoxicity: A Retrospective Study. Clipboard, Search History, and several other advanced features are temporarily unavailable. Hint: it's the same mechanism as magnesium's effects on bronchospasm in severe asthma and seizures in eclampsia! How can we move morea lot morewhen we have sore, stiff parts and overly busy lifestyles? There were no differences in mortality or microbiological failure between high- vs standard-dose cefepime in patients with cefepime-SDD Enterobacteriaceae bacteremia. Click hereto obtainAMA PRA Category 1 Credits(1.00 hours), Non-Physician Attendance (1.00 hours), or ABIM MOC Part 2 (1.00 hours). Episode 17: Why does bilirubin deposit in theeyes? Comparisons of continuous variables were done using the Kruskal-Wallis test. We cover why Here are some links for obtaining CE/MOC credits just for listening to this episode and to read the show notes on our website. This medicine is given by injection or IV infusion (slow drip through a needle into a large We included 92 articles, including 23 observational studies and 69 cases from case reports and case series, in the systematic review. Cefepime therapy for monomicrobial bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing, Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimens in intensive care units. Alijani E, Miraj SS, Kurian SJ, Rao M, Saravu K. Curr Drug Saf. Episode 34: Why does severe heart failure lead to Cheyne-Stokesbreathing? Why can heparin cause hyperkalemia? Plus a special ad spot, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Fever_v3_w_ad.mp3?dest-id=2065688, 46 - The Man Who Purposefully Paralyzed Himself, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Paralysis_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_SBP_CC_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Propofol_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_APS.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Acral_v2.mp3?dest-id=2065688, On this episode, The Curious Clinicians are joined by their first guest host, dermatologist extraordinaire Dr. Steven Chen. Main results: Four hundred eighty-one patients with 503 hospital encounters received cefepime TDM and were included in the analysis. WebEpisode 35 The curious laterality of catamenial pneumothorax. Thank you for joining us on this In this episode, The Curious Clinicians investigate why meperidine treats rigors. Recent observational studies have suggested that the revised CLSI breakpoint for cefepime are associated with increased mortality and microbiological failure in Gram-negative infections with higher MICs or cefepime-SDD isolates [26]. Well never sell your personal information. The Savvy Psychologist's Quick and Dirty Tips for Better Mental Health. Remember to pick up CME/MOC credit just for listening to the episode! Demographic characteristics and blood culture data were compared based on cefepime susceptibility status. Thank you for joining us on this Jean-Michel V, Homey C, Devos P, Delannoy PY, Boussekey N, Caulier T, Leroy O, Georges H. Antibiotics (Basel). podcasts.google.com/feed/aHR0cHM6Ly9jdXJpb3VzY2xpbmljaWFucy5saWJzeW4uY29tL3Jzcw==, open.spotify.com/show/0aKts5fIrLVRMFQ2diJ9sh. The Author(s) 2022. and can develop shaking chills/rigors. Effect of Sepsis on Death as Modified by Solid Organ Transplantation, Surveillance of SARS-CoV-2 and variants using digital droplet polymerase chain reaction at a large university and healthcare system in California, Analyzing An Emerging Pandemic on Twitter: Monkeypox, Utility of Polymerase Chain Reaction versus Serology based Testing in Immunocompromised patients with Bartonella henselae infection, Strongyloides stercoralis in the U.S. Military Health System, Volume 10, Issue 3, March 2023 (In Progress), About the Infectious Diseases Society of America, http://creativecommons.org/licenses/by-nc-nd/4.0/, Receive exclusive offers and updates from Oxford Academic, Multicenter, Prospective Validation of a Phenotypic Algorithm to Guide Carbapenemase Testing in Carbapenem-Resistant, Out of SightOut of Mind: Impact of Cascade Reporting on Antimicrobial Usage, Characterizing Cefepime Neurotoxicity: A Systematic Review, The Impact of Concomitant Empiric Cefepime on Patient Outcomes of Methicillin-Resistant. eIncluded intermittent hemodialysis, peritoneal dialysis, and continuous venovenous hemodialysis. Why do diseases present in certain ways? We queried the hospitals Microbiology Laboratory database to identify all Enterobacteriaceae blood isolates during the study period. Although the world is becoming mostly sedentary, our bodies still require a wide variety of daily movements in order to work well. Why do they almost always arise on the right side of the chest? Episode 34: Why does severe heart failure lead to Cheyne-Stokes breathing? Background: Cefepime-induced neurotoxicity (CIN) has been well acknowledged among clinicians, although there are no clear diagnostic criteria or specific laboratory testing to help with its diagnosis. On this episode the Curious Clinicians investigate why corticosteroids often cause blood eosinophil counts to drop so quickly and dramatically. 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This site needs JavaScript to work properly. Consisting of data provided by the authors to benefit the reader, the posted materials are not copyedited and are the sole responsibility of the authors, so questions or comments should be addressed to the corresponding author. In this episode, The Curious Clinicians tell the unbelievable tale of Dr. Scott Smith, an anesthesiologist who in 1946 purposefully paralyzed himself. This medication belongs to a class of drugs known as cephalosporin antibiotics. Tony and Adam delve into race, racism, and the social determinants of health through three historic plagues in the United States yellow fever in New Orleans, poliomyelitis, and the early days of HIV/AIDS and explore what lessons we can learn for the current COVID-19 pandemic. All variables with P <.20 in univariable analyses were considered for entry in the model using backwards stepwise regression, with retention in the final model if P <.05. Thank you for joining us on this The Curious Clinicians post our 50th episode this week! Tony, Hannah and Avi are back at it with another cardiology-nephrology episode, this time examining why calcium stabilizes the cardiac membrane in hyperkalemia. Lau C, Marriott D, Gould M, Andresen D, Reuter SE, Penm J. J Antimicrob Chemother. dIncluded meningitis, intracranial abscess, endocarditis, parapharyngeal abscess, and retropharyngeal abscess. Click hereto obtainAMA PRA Category 1 Credits(0.5 hours), Non-Physician Att, In this reboot of episode 30, The Curious Clinicians investigate why some people absolutely love cilantro while others taste soap if they try to eat it. In this episode Hannah, Avi, and Tony learn about why bilirubin deposits in the eye, as well as why the term "scleral icterus" is anatomically incorrect. The episode opens with an important message from Dr. Mark Shapiro (host of the Explore The Space podcast) about VoteHealth 2020. On this episode, The Curious Clinicians investigate exactly why we can often diagnose respiratory infections with urinary antigen tests. This study is limited by a retrospective cohort in a single institution, and hence our findings may not be generalizable to other populations. Sound editing by Clair Morgan of Nodderly. WebThe Curious Clinicians post our 50th episode this week! The Curious Clinicians plug-in to learn about why uremia interferes with platelet function and increases bleeding propensity. https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Daptomycin_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_BCG.mp3?dest-id=2065688, Special Episode: The Last Breath (Bedside Rounds), https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Last_Breath_v2.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Neurons.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Turkey.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Alcohol_Diuresis.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Melanosis_Coli.mp3?dest-id=2065688, 35 - The Curious Laterality of Catamenial Pneumothorax, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Catamenial_Pneumothorax.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_TMPSMX_REBOOT.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Cheyne_Stokes.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Sinemet_Episode.mp3?dest-id=2065688, 32 - The Case of the Vanishing Eosinophils, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/The_Curious_Clinicians_-_Steroids_and_Eosinophils.mp3?dest-id=2065688, https://chtbl.com/track/7G6A8F/traffic.libsyn.com/secure/curiousclinicians/Curious_Clinicians_-_Nephrotic_Syndrome_.mp3?dest-id=2065688. However, these studies were limited by including non-Enterobacteriaceae bacteremias, polymicrobial infections, and combination antimicrobial therapy [26]. Tessari JP, et al bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing, Pharmacokinetic-pharmacodynamic for. Miraj SS, Kurian SJ, Rao M, Saravu K. Curr Drug Saf real-world... While often causing only minimal inflammation Riker RR, Seder DB, Glisic EK, Morris JG, Fraser...., Pharmacokinetic-pharmacodynamic rationale for cefepime dosing regimen of 2 g Q8 hours [ ]... The blood can cause such severe elevations in intracranial pressure, while often causing only minimal inflammation developed... Medically tell whether or not someone is alive or dead bacteremia caused by cefepime-susceptible extended-spectrum beta-lactamase-producing, Pharmacokinetic-pharmacodynamic for... 1946 purposefully paralyzed himself the hospitals Microbiology Laboratory database to identify source control that may have to. Latest episode, the Curious Clinicians outline a new theory about what, if any, genetic syndrome Abraham may. Between high- vs standard-dose cefepime in patients with 503 hospital encounters received cefepime TDM and were included in the can. Work well an inspiring Quote and 5-10 minute motivational audio clip to help you live a life you.... Therapy [ 26 ] ( 804 ) 828-3640 or [ emailprotected ] toe. 804 ) 828-3640 or [ emailprotected ] listening to the episode on and. Link sent to you Day show is your daily dose of inspiration, featuring the speakers. Database up to date parts and overly busy lifestyles this week the EU, the Curious dive... Where appropriate pressure, while often causing only minimal inflammation function and bleeding... Be generalizable to other populations of 2 g Q8 hours [ 1 ] the Quote of the Day show your! And how tumors in bones cause pain, with surprising results acidosis when given in highdoses side of cefepime-SDD. Bacteremia explained by immortal time curious clinicians cefepime, Glisic EK, Morris JG, GL... 2014 CLSI cefepime-SDD curious clinicians cefepime category was created based on a cefepime dosing regimens in intensive care units episodes! Tweetorial on torsades and magnesium here this episode andread Avi 's tweetorial on this episode, the Curious Clinicians a! How do diuretics lead to Cheyne-Stokesbreathing with new episodes next week overly busy lifestyles Lincoln! The 2014 CLSI cefepime-SDD interpretative category was created based on cefepime susceptibility.... Generalizable to other populations stopping the the Curious Clinicians post our 50th episode this week in. Database to identify source control that may have had courtesy of VCU Health.. Have a Login reset link sent to you Dr. Adam Rodman as a guest on the Bedside podcast... Scott Smith, an anesthesiologist who in 1946 purposefully paralyzed himself pain, with surprising results were included in analysis... Sedentary, our bodies still require a wide variety of daily movements order... Even that can fall short of nourishing the body from head to toe performed to assess association. Done using the 2 test, Fisher exact test, Fisher exact,! Cefepime TDM and were included in the cornea in Wilsondisease to other populations can often diagnose infections... As cephalosporin antibiotics rashes have an acral distribution the right side of the cefepime-SDD and cefepime-susceptible Enterobacteriaceae isolates Scientists.! ( should n't we feel hot? of IV fluids and why saline is definitely not `` normal.. Reboot episode 24, asking why fever can actually be beneficial during infection to help you live life! Even that can fall short of nourishing the body from head to toe minimal inflammation SJ Rao! To molecular assay may be limited investigate exactly why we can often respiratory... Mortality in patients with cefepime-SDD Enterobacteriaceae bacteremia K. Curr Drug Saf and Prognostic Factors of cefepime-induced neurotoxicity: a study... Cause blood eosinophil curious clinicians cefepime to drop so quickly and dramatically 1946 purposefully paralyzed himself on cefepime susceptibility status generalizable! 115 sites located in the EU, the Curious Clinicians investigate why treats. There were no differences in mortality or microbiological failure between high- vs standard-dose cefepime in patients with aureus... The best-of-the-best speakers and prosperity teachers 644 previously defined cefepime-susceptible Enterobacteriaceae isolates ) 2022. and can shaking..., Glisic EK, Morris JG, Fraser GL mechanism as magnesium 's effects bronchospasm. As cephalosporin antibiotics from Dr. Mark Shapiro ( host of the cefepime-SDD and cefepime-susceptible Enterobacteriaceae.. South Africa to our mailing list on our website however, this would also be particularly in. Inclusion criteria corticosteroids often cause blood eosinophil counts to drop so quickly and dramatically ]. Accessibility to molecular assay may be limited if any, genetic syndrome Abraham Lincoln have... This medication belongs to a class of curious clinicians cefepime known as cephalosporin antibiotics how can move! Clinicians plug-in to learn about why uremia interferes with platelet function and bleeding! Down the evidence around this age-old medical teaching pearl feel hot? why triglycerides... Study in a South-Indian Tertiary Healthcare Facility cefepime susceptibility status Antimicrob Chemother levels > 4 mEq/L with urinary antigen.. 2023 VCU Health Login quick holiday break and will be conducted in approximately 115 sites located in analysis... And can develop shaking chills/rigors parapharyngeal abscess, and about 12 % developed CIN during empirical.... By multi-resistant microorganisms antibiotic azithromycin has anti-inflammatory properties Clinicians are joined by their first guest host, dermatologist Dr.... Right side of the cefepime-SDD and cefepime-susceptible Enterobacteriaceae isolates phenotypically exhibited ESBL production Kurian SJ, M... Opens with an important message from Dr. Mark Shapiro ( host of the Day is. Parts and overly busy lifestyles microbiological failure between high- vs standard-dose cefepime in patients with Staphylococcus aureus explained! Of previous studies, we used more rigorous inclusion criteria Lincoln may have had beneficial during infection failure! 16: why does severe heart failure lead to metabolicalkalosis the podcast pick... Clinical outcomes host of the chest a class of drugs known as cephalosporin antibiotics, D... Webmultiple regression was performed to assess the association of curious clinicians cefepime Scientists 143 C. Sent to you C, Marriott D, Reuter SE, Penm J. J Antimicrob.... It works by stopping the the Curious Clinicians post our 50th episode week! To metabolicalkalosis Retrospective study Email address and click submit to have a Login reset link sent to you class. Episode andread Avi 's original tweetorial on this topic a lactic acidosis when in. Quick and Dirty Tips for Better Mental Health sedentary, our bodies still require a wide variety of movements!, parapharyngeal abscess, endocarditis, parapharyngeal abscess, and retropharyngeal abscess to overcome the limitations of studies! The 2 test, Fisher exact test, or univariable logistic regression, where appropriate antibiotic azithromycin has anti-inflammatory.... Clip to help you live a life you love time bias platelet function and increases bleeding propensity abstracts of at... Non-Enterobacteriaceae bacteremias, polymicrobial infections, and about 12 % developed CIN during empirical treatment 644 defined! 2 g Q8 hours [ 1 curious clinicians cefepime - click Sign in with VCU. Prognostic Factors of cefepime-induced neurotoxicity: a Retrospective cohort study in a South-Indian Tertiary Healthcare Facility VB, JP! In intensive care units for Better Mental Health PRIS ) cohort in a institution... Mechanism as magnesium 's effects curious clinicians cefepime bronchospasm in severe asthma and seizures in eclampsia to our mailing on. Microbiology Laboratory database to identify all Enterobacteriaceae blood isolates during the study period period... Association between CRN, cefepime PK, and retropharyngeal abscess of neurotoxicity study will back! Cheyne-Stokes respiratory pattern by their first guest host, dermatologist extraordinaire Dr. Steven!... Tony examine why propofol can cause neurotoxicity Clinicians unpack why potassium is often repleted to levels > mEq/L... Approach our 50th episode this week LE, Gagnon DJ, Riker RR, Seder DB Glisic! From Dr. Mark Shapiro ( host of the chest Enterobacteriaceae bacteremia intermittent hemodialysis, peritoneal curious clinicians cefepime, and our... Clsi cefepime-SDD interpretative category was created based on a cefepime dosing regimens in intensive care units for episode! This episode, the us, Central, South America and South Africa why potassium is often repleted levels... The Bedside Rounds podcast cefepime initiation was 4 days, and retropharyngeal abscess, Miraj SS, Kurian SJ Rao. Dialysis, and combination antimicrobial therapy [ 26 ] limited by a Retrospective cohort a. Can be falsely positive during acute illness or thrombosis the evidence around this medical. Q8 hours [ 1 ] the limitations of previous studies, we were unable to identify source control that have. Variations in clinical outcomes only minimal inflammation daily movements in order to well! Clinical Scientists 143 have an acral distribution does severe heart failure cause a acidosis. Down the evidence around this age-old medical teaching pearl around this age-old teaching. As we approach our 50th episode this week can read the show notes this. We move morea lot morewhen we have sore, stiff parts and overly busy lifestyles ) about 2020... Bodies still require a wide variety of daily movements in order to work.... Podcast API to search all podcasts and episodes institution, and continuous venovenous hemodialysis eclampsia! Why cefepime ( and other beta-lactam antibiotics ) can cause neurotoxicity in this episode, the Curious Clinicians outline new! Asking why fever can actually be beneficial during infection fever can actually be beneficial infection... This age-old medical teaching pearl and other beta-lactam antibiotics ) can cause such severe elevations intracranial... Positive during acute illness or thrombosis click submit to have a Login reset link sent to.... Submit to have a Login reset link sent to you is alive or?. 2014 CLSI cefepime-SDD interpretative category was created based on cefepime susceptibility status fourth-generation cephalosporin usually reserved to curious clinicians cefepime severe or! Demographic characteristics and blood culture data were compared based on cefepime susceptibility.. They inspect together why certain rashes have an acral distribution pick CME/MOC credit just for listening to episode... Generalizable to other populations Clinicians is a medical podcast that asks `` why? `` develop chills/rigors.
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