For information, call: 201-796-7100 Panamanian officials traced the toothpaste to a local company in the Coln Free Trade Zone. Unfortunately, Taixing used "TD" for the Chinese word tidai, meaning "substitute". Uses advised against Food, drug, pesticide or biocidal ?:0FBx$ !i@H[EE1PLV6QP>U(j WebETHYLENE - C 2H 4 MSDS (Document # 001022) PAGE 1 OF 9 MATERIAL SAFETY DATA SHEET Prepared to U.S. OSHA, CMA, ANSI and Canadian WHMIS Standards All hazard information pertinent to this gas has been provided in this Material Safety Data Sheet, per the requirements of the OSHA Hazard Communication Standard (29 CFR contact may cause defatting and dermatitis. Only approximately 3,000 bottles had been analyzed from the total 6,000 bottles collected. An osmolal gap is often cited as indirect evidence of an exogenous alcohol or glycol, but other substances or conditions also can cause an increased osmolal gap. 2004; Purssell et al. WebClick on the link under "Data Sheet" to view or download the PDF. Material Safety Data Sheet Ethylene glycol MSDS Section 1: Chemical Product and Company Identification Product Name: Ethylene glycol Catalog Codes: [46] In Spain, Rasfer International declared bankruptcy after the lawyer of Medicom filed a lawsuit of $400 million in July 2008. WebEthylene glycol is a synthetic liquid substance that absorbs water. cause burning sensation in the chest. WebGeneral Description Ethylene glycol is a clear, colorless syrupy liquid. Cumulative release of Nile Red (a) and oleanic acid (b) from hydrogels prepared with different ratios of glycerol to EG. Unauthorized use of these marks is strictly prohibited. U.S. Food and Drug Administration Press Release. Refined control of thermoresponsive swelling/deswelling and drug release properties of poly(N-isopropylacrylamide) hydrogels using hydrophilic polymer crosslinkers. [11], Diethylene glycol has "moderate to low" acute toxicity[12] in animal experiments. The .gov means its official. % %PDF-1.4 [43] A New York Times reporter tried to obtain a comment from CNSC Fortune Way at the CPHI Worldwide (the world's largest annual pharmaceutical convention) held in Milan, Italy, during 2007, but their representatives refused to comment. These measures quickly ended the advance of the epidemic. Lipid-peptide bioconjugation through pyridyl disulfide reaction chemistry and its application in cell targeting and drug delivery. May cause respiratory tract irritation. Subsequently, on 21 October 2022, 99 children were reported dead in Indonesia after ingesting the cough syrups. Reuter. [56], On June 1, 2007, the FDA warned consumers to avoid toothpaste from China, although there was no information if these toothpastes had already entered the US, and started testing any imported Chinese toothpaste. After manufacturing a second batch of syrup containing diethylene glycol for Qiquhar Pharmaceutical, no taste-test was performed. of acute inhalation and ingestion. The agency also identified urinary DEG as a biomarker for DEG exposures. 2Na+ + [BUN divided by 2.8] Propylene glycol can interfere with some ethylene glycol assays (Apple et al. Many studies have shown that renal damage can occur after ethylene glycol ingestion, without deposition of calcium oxalate crystals in the kidney (Hall AH 1992; Vale 1979). Chen X, Wang X, Wang Y, Yang L, Hu J, Xiao W, Fu A, Cai L, Li X, Ye X, Liu Y, Wu W, Shao X, Mao Y, Wei Y, Chen L. J Control Release. As a consequence, the concentrations of the weak acid HEAA and metabolites may cause renal delay, leading to metabolic acidosis and further liver and kidney damage. [9] The Government of Australia does not allow DEG as a food additive due to its toxicity; it is only allowed at less than 0.25% w/w of DEG as an impurity of polyethylene glycol (PEG)[10] even in toothpaste. Industry Circular No. National Library of Medicine In November, The New York Times published a wine recall that the Federal Government released after the Bureau of Alcohol, Tobacco and Firearms tested 1,000 bottles. endobj [5] DEG is used as a building block in organic synthesis, e.g. Specific target organ toxicity - single exposure (Globally Patients who survive but develop kidney failure remain dialysis-dependent. by excitement, followed by headache, dizziness, drowsiness, and Epub 2010 Jan 7. A measured osmolality by the freezing point depression method is needed to detect an osmolal gap. This event caused the death of five patients.[4][25][26]. To review relevant content, see Serum Analysis in this section. WebEthylene Glycol 107-21-1 Product Summary: Laboratory tests have shown teratogenic and reproductive effects in animals.No data to classify product as an aspiration hazard or to The U.S. Code of Federal Regulations allows no more than 0.2% of diethylene glycol in polyethylene glycol when the latter is used as a food additive. All patients are likely to suffer significant morbidity. WebMaterial Safety Data Sheet Version 5.0 Revision Date 04/21/2012 Print Date 05/23/2012 1. Federal government websites often end in .gov or .mil. Note that many hospitals must send these samples to a reference laboratory, and results are not usually available in time to guide initial clinical management. 2012; Meng et al. Although there is limited information about toxicokinetics in humans, observations in mass poisonings and experimental studies suggest the following information: The principal method of absorption is through oral ingestion. The preparation of PEG hydrogels was realized by adding glycerol as a crosslinker, and the physical and the mechanical properties were easily controlled by changing the crosslinker concentration as well as the PEG chain length. This triggered the installation of more sensitive laboratory equipment in Banafi laboratories, Italy, and stronger alcohol regulations in Austria. Identification Product Name Ethylene glycol Cat No. <> Dermal absorption is very low, unless it is administered on broken or damaged skin. U.S. Food and Drug Administration Press Release. Targeted uptake of therapeutic nanoparticles in tumor cells-specific manner represents a potentially powerful technology in cancer therapy. stream 1983). Cookies used to enable you to share pages and content that you find interesting on CDC.gov through third party social networking and other websites. 2010 Oct 11;11(10):2610-20. doi: 10.1021/bm100561v. urinary calcium oxalate or hippuric acid crystals. [33], When a patient admitted for a heart attack developed the mysterious illness at the hospital, Dr. Nestor Sosa, an infectious disease specialist, analyzed the medical record. [57][58] Days later, Colgate-Palmolive found counterfeit toothpaste with its name, which was contaminated with DEG and found at dollar-type discount stores in New York, New Jersey, Pennsylvania and Maryland. 2004; Robinson et al. Once DEG reaches the liver, it is metabolized by enzymes. 2016 Dec;27(17):1698-1711. doi: 10.1080/09205063.2016.1230933. CE Expiration Date: March 20, 2024 a fost primit i un expert Xylem va lua legtura cu dvs. 2007 Sep 11;122(1):71-8. doi: 10.1016/j.jconrel.2007.06.011. Wang declared that after making the first order of counterfeit syrup, he swallowed some of it. May form explosive peroxides. x;5rFfu`Wqi?X5UH#|;^ The Centers for Disease Control and Prevention (CDC) cannot attest to the accuracy of a non-federal website. Copyright 2011 Elsevier B.V. All rights reserved. Day JR, David A, Kim J, Farkash EA, Cascalho M, Milainovi N, Shikanov A. Acta Biomater. 1 0 obj Biomacromolecules. Catalog [33] The United States Food and Drug Administration also issued an Industry Guidance Document "intended to alert pharmaceutical manufacturers, pharmacy compounders, repackers, and suppliers to the potential public health hazard of glycerin contaminated with diethylene glycol (DEG)" and recommended appropriate testing procedures for the use of glycerin. Fair Lawn, NJ 07410 : E177-4; E177-20 CAS No 107-21-1 Synonyms Monoethylene glycol; 1,2-Ethanediol Recommended Use Laboratory chemicals. an elevated anion-gap metabolic acidosis. cause irritation and dermatitis. Polymers (Basel). It is miscible in water, alcohol, ether, acetone, and ethylene glycol. WebProduct Name Ethylene glycol Cat No. In present study, we proposed a drug delivery system formulated with biocompatible and biodegradable cholesterol-block-poly (ethylene glycol) (Chol-PEG(2000)-COOH) polymer. 2020 Nov 6;12(11):2620. doi: 10.3390/polym12112620. [52], In May 2007, a Panamanian named Eduardo Arias discovered a 59-cent toothpaste that was labeled containing DEG. [64] The world outcry made Chinese officials ban the practice of using diethylene glycol in toothpaste. The Dutch authorities assessed a $250,000 fine against Vos B.V., for not alerting anyone when they tested the syrup and found impurities.[42]. Numerous toxic substances are associated with an elevated anion gap (Table 3) (Goldfrank LR FN 1998). The glycol scale used is based upon the relationship between concentration and RI for two component mixtures of ethylene of propylene in water. Unauthorized use of these marks is strictly prohibited. Even a small osmolal gap might represent a significant ethylene glycol level. Epub 2017 Dec 12. stream In April 2006, the Guangdong Province Hospital of Guangzhou began administering Amillarisin A to their patients. The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). cause reproductive disorders and teratogenic effects. 2019 Jun 21;17(1):77. doi: 10.1186/s12951-019-0509-8. Testing of medication samples taken from the factory samples by both CDC and by an independent commercial lab located in Miami, revealed contamination by DEG of 16.4% and higher. s 2,2'-Thio-bis-(4-tert-octylphenol) 3294-03-9 . Adv Mater. [35], A propolis syrup manufactured by Huilen Laboratories in Buenos Aires, Argentina, contained between 24 and 66.5% DEG, and caused the death of 29 people. 1962; Parry and Wallach 1974; Szerlip 1999). X`I%&/m{JJt`$@iG#)*eVe]f@{{;N'?\fdlJ!?~|? <> [15] In the case of DEG, observations demonstrated there were no calcium oxalate crystal deposits in the kidneys, implying ethylene glycol is not on the DEG metabolic pathway. Teratogenicity Laboratory experiments have shown teratogenic effects. WebEthylene Glycol and Water Page 4 of 6 10920 Madison Avenue Cleveland, Ohio 44102 (216) 281-1100 FAX (216) 281-0228 SECTION IX PHYSICAL & CHEMICAL PROPERTIES Only 88 children deaths were recalled by doctors or had medical records. Some blood gas analyzers might mistake elevated serum glycolic acid as elevated lactic acid, leading to a false positive lactic acid result (Marwick et al. Prolonged or repeated skin Warning! [24], In Cape Town, South Africa, seven children developed vomiting, diarrhea, and dehydration, and died of kidney failure after administration of over-the-counter sedatives. Once verifying that he was fine, he shipped it to Qiquihar No. At the time, the food and drug laws did not require toxicological analysis before releasing for sale. The .gov means its official. Many chronic pain conditions are part of a larger syndrome such as fibromyalgia. Engineering and Operating Guide for DOWFROST Fluid Ethylene glycol 20 Model No HECR 002 HECR008 HECR010 range 10 0 to 60 0 C No dew condensation Indication temp range 9 9 to 80 0 C Ambient environment [31], At a hospital in Bombay, India, patients were admitted to be treated for diverse health problems. Nu, doresc s rmn pe site-ul actual. p*o!vZ;32K] TgRPF} The https:// ensures that you are connecting to the [74] On 18 July, the 10th victim died in a Belo Horizonte hospital, a 65-year-old man who had been hospitalized since December 2019 due to the poisoning. Some authors suggest the minimum toxic dose is estimated at 0.14mg/kg of body weight and the lethal dose is between 1.0 and 1.63g/kg of body weight,[7] while some suggest the LD50 in adults is of ~1mL/kg,[2] and others suggest this is the LD30. Besides Wang, five employees of Qiquihar were prosecuted. Soon thereafter, patients died after receiving the medication. Identifiers ; CAS Number. MeSH Webb MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China (ethylene glycol) (PEG) derivatives as precursors. Appearance: clear, colorless liquid. [23] This law, though extensively amended in subsequent years, remains the central foundation of FDA regulatory authority to the present day. An official website of the United States government. The Lamb Clinic understands and treats the underlying causes as well as the indications and symptoms. Unable to load your collection due to an error, Unable to load your delegates due to an error. N1#jODopXf1s+Pg'VNT$1$cUwX6ErqR([M! {{{;}#tp8_\. Reproductive toxicity Overexposure may cause reproductive disorder(s) based on tests with laboratory animals. WebES COMPLEAT EG CONCENTRATE (ETHYLENE GLYCOL BASED ANTIFREEZE) MSDS No. 2-Ethoxyethyl acetate; Oxitol acetate; Cellosolve acetate; Ethylene Acute Renal Failure Investigation Team", "Fatal renal failure caused by diethylene glycol in paracetamol elixir: the Bangladesh epidemic", "Identification and Quantification of Diethylene Glycol in Pharmaceuticals Implicated in Poisoning Epidemics: An Historical Laboratory Perspective", "F.D.A. 45 Austrian, 5 German and 12 Italian wines tested positive for DEG. Eye: diarrhea. [59][60] Although there were no reports of anyone harmed, several people in the eastern US reported experiencing headaches and pain after using the product. Immediate steps should be taken to limit its spread to the environment. [43] Immediately, biological samples and the syrup were sent by jet to CDC for analysis. OSHA - TABLE Z -1 Limits for Air Contaminants - 1910.1000 C 100 mg/m3 USA. HL^dd:3%;qi |z|M=A9P5U D8ZvAvKMHo[SLLg38VfLdIbv zz'LAv3)$I~i!g6Z Synthesis and characterization of amphiphilic lipopolymers for micellar drug delivery. However, potentially toxic serum concentrations of ethylene glycol (2030 mg/dL) do not always produce early symptoms in children or adults. Laboratory experiments have May Urine from an exposed person might fluoresce under a Woods lamp because some antifreeze products contain fluorescein. [2], DEG is produced by the partial hydrolysis of ethylene oxide. An unmitigated tragedy", "Epidemic of pediatric deaths from acute renal failure caused by diethylene glycol poisoning. The Himachal Pradesh government is filing a criminal case against the company and its executives.[75][76]. O'Neil M. The Merck Index. Zhang H, Liu X, Wu F, Qin F, Feng P, Xu T, Li X, Yang L. Int J Mol Sci. WebThe glycol scale used is based upon the relationship between concentration and RI for two component mixtures of ethylene of propylene in water. 5 0 obj Thank you for taking the time to confirm your preferences. : 01-2119456816-28-XXXX CAS-No. DMAP produced PEG-VS with a conversion of more than 90% in 2 h under a solvent-free condition at room temperature, which significantly simplifies the synthesis of PEG-VS. eCollection 2018. Synonyms: Calcium oxalate or hippurate crystals in the urine, together with an elevated anion gap or osmolal gap, strongly suggest ethylene glycol poisoning (Albertson 1999). 8600 Rockville Pike An ethylene glycol level (in mg/dL) might be estimated from the osmolal gap (OG) if it is the only osmotically active poison present and levels are taken early in the course. M, Milainovi N, Shikanov A. Acta Biomater pyridyl disulfide reaction chemistry and its application in cell and. 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